肿瘤坏死因子α(TNFa)活性蛋白

Active Tumor Necrosis Factor Alpha (TNFa)

DIF; TNF-A; TNFSF2; Cachectin; Tumor Necrosis Factor Ligand Superfamily Member 2

  • 肿瘤坏死因子α(TNFa)活性蛋白 产品包装(模拟)
  • 肿瘤坏死因子α(TNFa)活性蛋白 产品包装(模拟)
  • 肿瘤坏死因子α(TNFa)活性蛋白 Gene sequencing
  • APA133Mu01.jpg Figure. SDS-PAGE
  • 肿瘤坏死因子α(TNFa)活性蛋白 Western Blot, Sample: APA133Mu01; Antibody: PAA133Mu01
  • Certificate 通过ISO 9001、ISO 13485质量体系认证

活性实验

Figure 1. Cell apoptosis of A549 cells after stimulated by TNFa.
TNFa, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, inflammation and inhibit tumorigenesis. As reported, TNFa could inhibit the proliferation and induce apoptosis of A549 cells, and the concentration of IL-1β in cell supernatant will increase after stimulation. A549 cells were incubated in DMEM with TNFa (1ng/mL, 10ng/mL) for 2h, 4h, 8h, 24h, 48h, then cells were observed by inverted microscope and IL-1β in cell supernatant was detected by ELISA. Cell apoptosis of A549 after incubation of 48h was shown in Figure 1. (A)A549 cells cultured in DMEM, stimulated with 1ng/mL TNFa for 48h;
(B)A549 cells cultured in DMEM, stimulated with 10ng/mL TNFa for 48h;
A549 cells cultured in DMEM for 48h.

Table 1. ELISA detection of IL-1β expression from A549 cells by TNFa.
Effect of TNFa on the expression of IL-1β is shown in Table 1.

用法

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

储存

避免反复冻融。2-8°C不超过一个月,-80°C不超过12个月。

稳定性

热稳定性以损失率显示。损失率是由加速降解试验决定,具体方法如下:在37°C孵育48小时,没有显著的降解或者沉淀产生。保质期内,在适当的条件下存储,损失率低于5%。

相关产品

编号 适用物种:Mus musculus (Mouse,小鼠) 应用(仅供研究使用,不用于临床诊断!)
APA133Mu01 肿瘤坏死因子α(TNFa)活性蛋白 Cell culture; Activity Assays.
APA133Mu61 肿瘤坏死因子α(TNFa)活性蛋白 Cell culture; Activity Assays.
RPA133Mu02 肿瘤坏死因子α(TNFa)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
EPA133Mu61 肿瘤坏死因子α(TNFa)真核蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
RPA133Mu01 肿瘤坏死因子α(TNFa)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
PAA133Mu01 肿瘤坏死因子α(TNFa)多克隆抗体 WB; IHC; ICC; IP.
PAA133Mu02 肿瘤坏死因子α(TNFa)多克隆抗体 WB; IHC; ICC; IP.
PAA133Mu06 肿瘤坏死因子α(TNFa)多克隆抗体 WB; IHC; ICC; IP.
LAA133Mu71 肿瘤坏死因子α(TNFa)多克隆抗体(生物素标记) WB; IHC; ICC.
MAA133Mu21 肿瘤坏死因子α(TNFa)单克隆抗体 WB; IHC; ICC; IP.
SEA133Mu 肿瘤坏死因子α(TNFa)检测试剂盒(酶联免疫吸附试验法) Enzyme-linked immunosorbent assay for Antigen Detection.
MEA133Mu 肿瘤坏死因子α(TNFa)检测试剂盒(酶联免疫吸附试验法,小样本) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA133Mu 肿瘤坏死因子α(TNFa)检测试剂盒(化学发光免疫分析法) Chemiluminescent immunoassay for Antigen Detection.
KSA133Mu01 肿瘤坏死因子α(TNFa)检测试剂盒DIY材料(酶联免疫吸附试验法) Main materials for "Do It (ELISA Kit) Yourself".

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Sci Rep The C-terminal Domain Supports a Novel Function for CETPI as a New Plasma Lipopolysaccharide-Binding Protein [PubMed: 26537318]
Immunol Res Construction of recombinant Mip-FlaA dominant epitope vaccine against Legionella pneumophila and evaluation of the immunogenicity and protective immunity [PubMed: 26607265]
Physiol Res Heart rate variability and inflammatory response in rats with lipopolysaccharide-induced endotoxemia. [PubMed: 26674290]
Cell Mol Neurobiol Hypericum Perforatum Hydroalcoholic Extract Mitigates Motor Dysfunction and is Neuroprotective in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson’s Disease [PubMed: 26119304]
The Journal of Nutritional Biochemistry Protective role of n6/n3 PUFA supplementation with varying DHA/EPA ratios against atherosclerosis in mice [Pubmed:27142749]
Scientific Reports Cellular uptake of exogenous calcineurin B is dependent on TLR4/MD2/CD14 complexes, and CnB is an endogenous ligand of TLR4 [Pubmed:27090571]
Journal of Food Science  Effects of Hyriopsis cumingii Polysaccharides on Mice Immunologic Receptor, Transcription Factor, and Cytokine [Pubmed:27061742]
The Journal of Biochemistry Role of reactive oxygen species-mediated MAPK and NF-κB activation in polygonatum cyrtonemalectin-induced apoptosis and autophagy in human lung adenocarcinoma A549 cells [Pubmed:27318358]
Veterinary Immunology and Immunopathology Neutrophil gene dynamics and plasma cytokine levels in dairy cattle during peri-implantation period [Pubmed:27090626]
American Journal of Translational Research Human mesenchymal stem cells attenuate experimental bronchopulmonary dysplasia induced by perinatal inflammation and hyperoxia [Pubmed:27158330]
Cellular and Molecular Neurobiology Hypericum Perforatum Hydroalcoholic Extract Mitigates Motor Dysfunction and is Neuroprotective in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson’s Disease [Pubmed:26119304]
Nutrition Journal Influence of diet on leukocyte telomere length, markers of inflammation and oxidative stress in individuals with varied glucose tolerance: a Chinese population study [Pubmed:27071648]
Journal of Translational Medicine Effectiveness of pure argon for renal transplant preservation in a preclinical pig model of heterotopic autotransplantation [Pubmed:26847569]
Swimming training attenuates the morphological reorganization of the myocardium and local inflammation in the left ventricle of growing rats with untreated experimental diabetes. [Pubmed:26896925]
Advances in Experimental Medicine and Biology  Antiinflammatory Effect of N-Acetylcysteine Combined with Exogenous Surfactant in Meconium-Induced Lung Injury [Pubmed:27283193]
Neuroscience Bexarotene protects against traumatic brain injury in mice partially through apolipoprotein E [Pubmed:27235741]
Research in Veterinary Science A chimeric protein composed of the binding domains ofClostridium perfringens phospholipase C and Trueperella pyogenes pyolysin induces partial immunoprotection in a mouse model [Pubmed:27473983]
Neurological Research: A Journal of Progress in Neurosurgery, Neurology and Neurosciences Telmisartan ameliorates oxidative stress and subarachnoid haemorrhage-induced cerebral vasospasm [Pubmed:27078703]
SpringerPlus Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression ofHMGB1/RAGE/NF-ΚB pathway. [Pubmed:27026909]
Hepatology Research Amelioration of free fatty acid-induced fatty liver by quercetin-3-O-β-D-glucuronide through modulation ofperoxisome proliferator-activated receptor-alpha/sterol reCavia (Guinea pig )latory element-binding protein-1c signaling. [Pubmed:26190035]
Biomedicine & Pharmacotherapy Investigation of the anti-glioma activity of Oviductus ranae protein hydrolysate [Pubmed:27261592]
PLoS One Lipopolysaccharide Cross-Tolerance Delays Platelet-Activating Factor-Induced Sudden Death in Swiss Albino Mice: Involvement of Cyclooxygenase in Cross-Tolerance [Pubmed:27064683]
Animal Anterior pituitary influence on adipokine expression and secretion by porcine adipocytes. [Pubmed:27074715]
Iranian Journal of Basic Medical Sciences Neuroprotective effects of atomoxetine against traumatic spinal cord injury in rats [pmc:PMC4834117]
J Stroke Cerebrovasc Dis. Curcumin Attenuates Inflammation, Oxidative Stress, and Ultrastructural Damage Induced by Spinal Cord Ischemia–Reperfusion Injury in Rats [Pubmed:26935117]
Int J Clin Exp Pathol Effects of Dectin-1 on the mast cells in allergic conjunctivitis and its underlying mechanism [files:ijcep0019305.pdf]
Int J Biochem Cell Biol. Uroprotective effect of oleuropein in a rat model of hemorrhagic cystitis. [Pubmed:26905436]
Life Sci. Carcinoembryonic antigen related cellular adhesion molecule 1 alleviates dextran sulfate sodium-induced ulcerative colitis in mice [Pubmed:26898127]
Mediators of Inflammation Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters [journals:6423637]
Biol Trace Elem Res. Analysis of Ionomic Profiles of Canine Hairs Exposed to Lipopolysaccharide (LPS)-Induced Stress [Pubmed:26758868]
Endocrine Effects of glucagon-like peptide-1 on advanced glycation endproduct-induced aortic endothelial dysfunction in streptozotocin-induced diabetic rats: possible roles of Rho kinase- and AMP kinase-mediated nuclear factor κB signaling pathways [Pubmed:26758998]
Am J Physiol Gastrointest Liver Physiol Inhibition of cyclooxygenase-2 alleviates liver cirrhosis via improvement of the dysfunctional Cavia (Guinea pig )t-liver axis in rats [Pubmed:27056726]
Braz Dent J Effect of 15% Alcohol Dependence on Alveolar Bone Loss and TNF-α Secretion in Wistar Rats [Pubmed:27058374]
Life Sci Cardioprotective effects of baicalein on heart failure via modulation of Ca(2+) handling proteins in vivo and in vitro [Pubmed:26706290]
Journal of Veterinary Research Comparison of laparoscopic and traditional abomasal cannulation in sheep [view:16]
Basic Clin Pharmacol Toxicol Neuroprotective Effect of Ginsenoside Rd in Spinal Cord Injury Rats [Pubmed:26833867]
Virol J Classical swine fever virus NS5A protein changed inflammatory cytokine secretion in porcine alveolar macrophages by inhibiting the NF-κB signaling pathway [Pubmed:27296632]
Clin Epigenetics. The bromodomain inhibitor N-methyl pyrrolidone reduced fat accumulation in an ovariectomized rat model [Pubmed:27110299]
Int J Mol Sci. Dexmedetomidine Protects Rat Liver against Ischemia-Reperfusion Injury Partly by the α2A-Adrenoceptor Subtype and the Mechanism Is Associated with the TLR4/NF-κB Pathway [Pubmed:27347929]
Journal of Neuroinflammation Upregulation of neuronal zinc finger protein A20 expression is required for electroacupuncture to attenuate the cerebral inflammatory injury mediated by the nuclear factor-kB signaling pathway in cerebral ischemia/reperfusion rats [pubmed:27716383]
Journal of traditional and complementary medicine. Antioxidant effects of Spirulina supplement against lead acetate-induced hepatic injury in rats. [pubmed:27774414]
Front Pharmacol Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata [pubmed:27803670]
BMC Veterinary Research Lymphocytic, cytokine and transcriptomic profiles in peripheral blood of dogs with atopic dermatitis [pubmed:27553600]
Oxidative Medicine and Cellular Longevity Hyperglycemia Aggravates Hepatic Ischemia Reperfusion Injury by Inducing Chronic Oxidative Stress and Inflammation. [pubmed:27656261]
Journal of Pre-Clinical and Clinical Research Circulating cytokeratin-18 and tumour necrosis factor-α in patients with alcoholic liver cirrhosis [582a2e2208aef19cb8053ce8.pdf]
BMC Complementary and Alternative Medicine Effect of traditional Chinese medicine formula Sinisan on chronic restraint stress-induced nonalcoholic fatty liver disease: a rat study. [pubmed:28388904]
immunology letters Recombinant Mip-PilE-FlaA dominant epitopes vaccine candidate against Legionella pneumophila. [pubmed:28366526]
IUBMB Life. Elevated serum milk fat globule-epidermal growth factor 8 levels in type 2 diabetic patients are suppressed by overweight or obese status. [pubmed:28067023]
Lipids in Health and Disease Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice. [pubmed:28356106]
Journal of Functional Foods Eicosapentaenoic acid-enriched phospholipids improve atherosclerosis by mediating cholesterol metabolism [S1756464617300890]
biomedicine & pharmacotherapy Diosgenin ameliorates development of neuropathic pain in diabetic rats: Involvement of oxidative stress and inflammation. [pubmed:28033582]
Nutrition. Noni leaf and black tea enhance bone regeneration in estrogen-deficient rats. [pubmed:27908549]
Journal of diabetes investigation Circulating milk fat globule-epidermal growth factor 8 levels are increased in pregnancy and gestational diabetes mellitus. [pubmed:28035763]
International Journal of Molecular Medicine The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats [pubmed:27430552]
未查到 Clinical effect of electro-acupuncture on lung injury patients caused by severe [3162851.pdf]
Journal of Molecular and Cellular Cardiology Irisin improves perivascular adipose tissue dysfunction via regulation of the heme oxygenase-1/adiponectin axis in diet-induced obese mice [pubmed:27638193]
Springerplus Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathway [pubmed:27026909]
Andrology Chronic prostatitis/chronic pelvic pain syndrome impairs erectile function through increased endothelial dysfunction, oxidative stress, apoptosis, and corporal fibrosis … [doi:10.1111]
Cellular Physiology and Biochemistry The Neuroprotective Effect of Puerarin in Acute Spinal Cord Injury Rats. [pubmed:27576607]
Journal of Orthopaedic Surgery and Research  No midterm advantages in the middle term using small intestinal submucosa and human amniotic membrane in Achilles tendon transverse tenotomy [pubmed:27881176]
Atherosclerosis Iridoid–loganic acid versus anthocyanins from the Cornus mas fruits (cornelian cherry): Common and different effects on diet-induced atherosclerosis, PPARs … [S0021915016314046]
International Journal of Clinical and Experimental Pathology Level of serum apolipoprotein m and its diagnostic significance in inflammatory bowel disease [files:ijcep0033416.pdf]
Molecular Medicine Reports C‑reactive protein/oxidized low density lipoprotein/β2‑glycoprotein i complexes induce lipid accumulation and inflammatory reaction in macrophages via p38/mitogen‑ … [10.3892]
Physiological Research Lung inflammatory and oxidative alterations after exogenous surfactant therapy fortified with budesonide in rabbit model of meconium aspiration syndrome. [pubmed:28006947]
Molecular Medicine Reports Zisheng Shenqi decoction ameliorates monosodium urate crystal-induced gouty arthritis in rats through anti-inflammatory and anti-oxidative effects [pubmed:27432278]
The American Journal of Chinese Medicine Pinellia ternata Attenuates Mucus Secretion and Airway Inflammation after InhaledCorticosteroid Withdrawal in COPD Rats. [pubmed:27430907]
Cardiovascular Diabetology Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. [pubmed:27809851]
PLOS ONE Protective Effects of Bifidobacterium on Intestinal Barrier Function in LPS-Induced EnterocyteBarrier Injury of Caco-2 Monolayers and in a Rat NEC Model. [pubmed:27551722]
Food & Function Protective effects of fish oil on pre-diabetes: a lipidomic analysis of liver ceramides in rats. [pubmed:27722538]
PLOS ONE Mechanical Ventilation Alters the Development of Staphylococcus aureus Pneumonia in Rabbit. [pubmed:27391952]
The Journal of Comenius University in Bratislava Effects of Conventional Mechanical Ventilation Performed by Two Neonatal Ventilators on the Lung Functions of Rabbits with Meconium-Induced Acute Lung Injury [acm.2017.16.issue-3]
Journal of Physiology and Pharmacology Effects of budesonide on the lung functions, inflammation and apoptosis in a saline-lavagemodel of acute lung injury. [pubmed:28195073]
Applied Biochemistry and Biotechnology Protective Effect of Zingiber officinale Against Dalton's Lymphoma Ascites Tumour byRegulating Inflammatory Mediator and Cytokines. [pubmed:27435276]
Future Microbiology Transplantation of a bacterial consortium ameliorates trinitrobenzenesulfonic acid-induced colitisand intestinal dysbiosis in rats. [pubmed:27415182]
BioMed Research International Dihydromyricetin Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced DiabeticMice. [pubmed:28421194]
Saudi Journal of Gastroenterology Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice. [pubmed:27976641]
Parasites & Vectors Vaccination of rabbits with immunodominant antigens from Sarcoptes scabiei induced highlevels of humoral responses and pro-inflammatory cytokines but confers limited protection. [pubmed:27502394]
中国药物警戒 小剂量阿奇霉素对稳定期老年慢性阻塞性肺疾病患者外周血内TNF-α、IL-8、CRP水平及肺功能的影响 [Periodical_zgywjj201608004]
Oncotarget Poly(ADP-ribose) polymerase 1 inhibition protects cardiomyocytes from inflammation andapoptosis in diabetic cardiomyopathy. [pubmed:27027354]
Life Sciences Bone fracture healing is delayed in splenectomic rats [pubmed:27956350]
Journal of Ethnopharmacology Learning and memory improvement and neuroprotection of Gardenia jasminoides (Fructusgardenia) extract on ischemic brain injury rats. [pubmed:27940085]
Food Funct. Flavonoids from sea buckthorn inhibit the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through the MAPK and NF-κB pathways. [pubmed:28256654]
 Research in Veterinary The effect of feed supplementation with zinc chelate and zinc sulphate on selected humoral and cell-mediated immune parameters and cytokine concentration in … [S0034528816303162]
Mol Med Rep. Galectin-3 inhibition ameliorates hypoxia-induced pulmonary artery hypertension. [pubmed:27959409]
Parasitology. Nonsteroidal anti-inflammatory is more effective than anti-oxidant therapy in counteracting oxidative/nitrosative stress and heart disease in T. cruzi-infected mice. [pubmed:28134069]
Ren Fail.  Effect of concomitant administration of coenzyme Q10 with sitagliptin on experimentally induced diabetic nephropathy in rats. [pubmed:27841100]
PLoS One. Self-complementary adeno-associated virus serotype 6 mediated knockdown of ADAMTS4 induces long-term and effective enhancement of aggrecan in degenerative human nucleus pulposus cells: A new therapeutic approach for intervertebral disc disorders. [pubmed:28207788]
Sci Rep.  Comparison of human adipose stromal vascular fraction and adipose-derived mesenchymal stem cells for the attenuation of acute renal ischemia/reperfusion injury. [pubmed:28276451]
Cell Death Dis. Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy [pubmed:28333148]
Journal of Photochemistry and Photobiology B: Biology Efficacy of scaling and root planning with and without adjunct Nd:YAG laser therapy on clinical periodontal parameters and gingival crevicular fluid interleukin 1-beta and tumor necrosis factor-alpha levels among patients with periodontal disease: A prospective randomized split-mouth clinical study. [pubmed:28282558]
Journal of Cellular Physiology Autophagy maintains the integrity of endothelial barrier in LPS-induced lung injury. [pubmed:28328069]
Key Engineering Materials The Level of Inflammatory Cytokines and Antimicrobial Peptides after Composite Material Implantation and Contamination with Bacterial Culture. [16629795]
Biomedicine & pharmacotherapy= Biomedecine & pharmacotherapie Protective effects of N-acetylcystein and atorvastatin against renal and hepatic injury in a rat model of intestinal ischemia-reperfusion [pubmed:28273631]
Journal of Neurochemistry β‐Caryophyllene protects in vitro neurovascular unit against oxygen‐glucose deprivation and re‐oxygenation‐induced injury [pubmed:27565895]
Journal of Functional Foods Impact of purified oat 1-3, 1-4-β-d-glucan of different molecular weight on alleviation of inflammation parameters during gastritis [S1756464616303528]
International Journal of Stem Cell Research and Transplantation Protective Role of Bone Marrow Derived Mesenchymal Stem Cells-Conditioned Medium in the Infarcted Myocardium: The Potential Role of Selected Cytokines [IJST-2328-3548-04-803]
Домашня сторінка ВПЛИВ КРОВОВТРАТИ НА ДИНАМІКУ ВМІСТУ ЦИТОКІНІВ СИРОВАТКИ КРОВІ В ПЕРІОД ГОСТРОЇ РЕАКЦІЇ НА КРАНІОСКЕЛЕТНУ ТРАВМУ [83646]
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