转化生长因子β1(TGFb1)检测试剂盒(酶联免疫吸附试验法)

ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1)

TGF-B1; CED; DPD1; LAP; Camurati-Engelmann Disease; Latency-associated peptide

  • 转化生长因子β1(TGFb1)检测试剂盒(酶联免疫吸附试验法) 产品包装(模拟)
  • 转化生长因子β1(TGFb1)检测试剂盒(酶联免疫吸附试验法) 产品包装(模拟)
  • 转化生长因子β1(TGFb1)检测试剂盒(酶联免疫吸附试验法) 实验结果图
  • SEA124Ra.jpg 标准曲线图
  • Certificate 通过ISO 9001、ISO 13485质量体系认证

特异性

本试剂盒用于检测转化生长因子β1(TGFb1),经检测与其它相似物质无明显交叉反应。
由于受到技术及样本来源的限制,不可能完成对所有相关或相似物质交叉反应检测,因此本试剂盒有可能与未经检测的其它物质有交叉反应。

回收率

分别于定值血清及血浆样本中加入一定量的转化生长因子β1(TGFb1)(加标样品),重复测定并计算其均值,回收率为测定值与理论值的比率。

样本 回收率范围(%) 平均回收率(%)
serum(n=5) 96-103 101
EDTA plasma(n=5) 83-93 89
heparin plasma(n=5) 83-104 101

精密度

精密度用样品测定值的变异系数CV表示。CV(%) = SD/mean×100
批内差:取同批次试剂盒对低、中、高值定值样本进行定量检测,每份样本连续测定20 次,分别计算不同浓度样本的平均值及SD值。
批间差:选取3个不同批次的试剂盒分别对低、中、高值定值样本进行定量测定,每个样本使用同一试剂盒重复测定8次,分别计算不同浓度样本的平均值及SD值。
批内差: CV<10%
批间差: CV<12%

线性

在定值血清及血浆样本内加入适量的转化生长因子β1(TGFb1),并倍比稀释成1:2,1:4,1:8,1:16的待测样本,线性范围即为稀释后样本中转化生长因子β1(TGFb1)含量的测定值与理论值的比率。

样本 1:2 1:4 1:8 1:16
serum(n=5) 81-97% 97-104% 95-105% 98-105%
EDTA plasma(n=5) 96-103% 83-96% 78-93% 79-101%
heparin plasma(n=5) 92-101% 78-101% 88-103% 86-98%

稳定性

经测定,试剂盒在有效期内按推荐温度保存,其活性降低率小于5%。
为减小外部因素对试剂盒破坏前后检测值的影响,实验室的环境条件需尽量保持一致,尤其是实验室内温度、湿度及温育条件。其次由同一实验员来进行操作可减少人为误差。

实验流程

1. 实验前标准品、试剂及样本的准备;
2. 加样(标准品及样本)100µL,37°C孵育1小时;
3. 吸弃,加检测溶液A100µL,37°C孵育1小时;
4. 洗板3次;
5. 加检测溶液B100µL,37°C孵育30分钟;
6. 洗板5次;
7. 加TMB底物90µL,37°C孵育10-20分钟;
8. 加终止液50µL,立即450nm读数。

实验原理

将转化生长因子β1(TGFb1)抗体包被于96孔微孔板中,制成固相载体,向微孔中分别加入标准品或标本,其中的转化生长因子β1(TGFb1)与连接于固相载体上的抗体结合,然后加入生物素化的转化生长因子β1(TGFb1)抗体,将未结合的生物素化抗体洗净后,加入HRP标记的亲和素,再次彻底洗涤后加入TMB底物显色。TMB在过氧化物酶的催化下转化成蓝色,并在酸的作用下转化成最终的黄色。颜色的深浅和样品中的转化生长因子β1(TGFb1)呈正相关。用酶标仪在450nm波长下测定吸光度(O.D.值),计算样品浓度。

相关产品

编号 适用物种:Rattus norvegicus (Rat,大鼠) 应用(仅供研究使用,不用于临床诊断!)
RPA124Ra01 转化生长因子β1(TGFb1)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
APA124Ra01 转化生长因子β1(TGFb1)活性蛋白 Cell culture; Activity Assays.
PAA124Ra01 转化生长因子β1(TGFb1)多克隆抗体 WB; IHC; ICC; IP.
LAA124Ra81 转化生长因子β1(TGFb1)多克隆抗体(异硫氰酸荧光素标记) WB; IHC; ICC; IF.
LAA124Ra71 转化生长因子β1(TGFb1)多克隆抗体(生物素标记) WB; IHC; ICC.
MAA124Ra22 转化生长因子β1(TGFb1)单克隆抗体 WB; IHC; ICC; IP.
MAA124Ra23 转化生长因子β1(TGFb1)单克隆抗体 WB; IHC; ICC; IP.
MAA124Ra24 转化生长因子β1(TGFb1)单克隆抗体 WB; IHC; ICC; IP.
MAA124Ra21 转化生长因子β1(TGFb1)单克隆抗体 WB; IHC; ICC; IP.
MAA124Ra25 转化生长因子β1(TGFb1)单克隆抗体 WB; IHC; ICC; IP.
SEA124Ra 转化生长因子β1(TGFb1)检测试剂盒(酶联免疫吸附试验法) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA124Ra 转化生长因子β1(TGFb1)检测试剂盒(化学发光免疫分析法) Chemiluminescent immunoassay for Antigen Detection.
LMA124Ra 转化生长因子β1(TGFb1)等多因子检测试剂盒(流式荧光发光法) FLIA Assay for Antigen Detection.
KSA124Ra01 转化生长因子β1(TGFb1)检测试剂盒DIY材料(酶联免疫吸附试验法) Main materials for "Do It (ELISA Kit) Yourself".

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JOURNAL OF IMMUNOLOGY RESEARCH The Sufficient Immunoregulatory Effect of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation on Regulatory T Cells in Patients with … [Pubmed: 32411794]
Frontiers in Pharmacology M10, a Myricetin-3-ObD-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice [Pubmed: 33041798]
Food & Function Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial … []
Effect of metformin and indole-3-carbinol on a rat model of Parkinson's disease induced by 6-hydroxydopamine []
Research square Vitamin D Status in Dupuytren's Disease: Association with Clinical Status and Vitamin D Receptor Expression []
Phytomedicine Menthacarin attenuates experimental colitis []
Immunomodulatory effects of sCD83 via induction of TGF-β1 and IDO: an in vitro and rat orthotopic liver transplantation study []
BMC Complement Med Ther Suppression of autophagy through JAK2/STAT3 contributes to the therapeutic action of rhynchophylline on asthma [33413331]
Life Sci Celecoxib ameliorates liver cirrhosis via reducing inflammation and oxidative stress along spleen-liver axis in rats [33577848]
CLINICAL SCIENCE Berberine accelerated wound healing by restoring TrxR1/JNK in diabetes [33491733]
Bioact Mater New design to remove leukocytes from platelet-rich plasma (PRP) based on cell dimension rather than density [33842739]
Acta Biomater Highly interconnected inverse opal extracellular matrix scaffolds enhance stem cell therapy in limb ischemia [33878473]
Mol Cell Biochem Human umbilical cord-derived mesenchymal stem cells and their chondroprogenitor derivatives reduced pain and inflammation signaling and promote regeneration in?¡­ [33864569]
Cell Death & Disease Sodium/glucose cotransporter 1-dependent metabolic alterations induce tamoxifen resistance in breast cancer by promoting macrophage M2 polarization [34006822]
PLoS One Beneficial impact of cathelicidin on hypersensitivity pneumonitis treatment¡ªIn vivo studies [33999928]
Vascular pharmacology Nectin-4 promotes lymphangiogenesis and lymphatic metastasis in breast cancer by regulating CXCR4-LYVE1 axis [33945869]
Equine Vet J Limited added value of negative pressure wound therapy compared to calcium alginate dressings for second intention healing in a non©\contaminated and?¡­ [34115409]
Stem Cells International The Paracrine Effect of Adipose-Derived Stem Cells Orchestrates Competition between Different Damaged Dermal Fibroblasts to Repair UVB-Induced Skin?¡­ [33381190]
Journal of Pharmacy and Pharmacology Pharmacodynamic evaluation of dihydroxyflavone derivate chrysin in a guinea pig model of allergic asthma [33793800]
Bull. Egypt. Soc. Physiol. Sci. Flaxseed Oil Supplementation Afford Comparable Therapeutic effect to Metformin in Bleomycin Induced Pulmonary Fibrosis Rat model []
У¿¯ Role of Angiotensin II and Renal Nerves on TGF-b/SmadPathway in Diabetic Nephropathy Rat Model []
Bioactive Materials Calcium phosphate-based materials regulate osteoclast-mediated osseointegration []
Mediators of Inflammation Sparstolonin B Exerts Therapeutic Effects on Collagen-Induced Arthritis by Inhibiting the NLRP3 Inflammasome and Reducing the Activity of ¦Á1, 3 ¡­ []
Manuscript title Microparticles Containing MiR-625-5p In Coronary Artery Reduce Myocardial Fibrosis After Myocardial Infarction []
Andrology X‐ray micro‐computed tomography in the assessment of penile cavernous fibrosis in a rabbit castration model [34236146]
Aging Yiqi Jiemin decoction alleviates allergic rhinitis in a guinea pig model by suppressing inflammation, restoring Th1/Th2 balance, and improving cellular … [34315133]
Tissue Eng Regen Med Effect of Leukocyte-Platelet Rich Fibrin (L-PRF) on Tissue Regeneration and Proliferation of Human Gingival Fibroblast Cells Cultured Using a Modified Method [34339025]
Am J Transl Res Wuling San and Xiao Chaihu Decoction affect airway inflammatory response and airway smooth muscle cell proliferation in mice with allergic asthma via miR … [34786062]
Biomacromolecules In Situ Forming Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration [34723499]
Brain Sci Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial … [34942919]
Biomedicines Exploring Epithelial–Mesenchymal Transition Signals in Endometriosis Diagnosis and In Vitro Fertilization Outcomes [34829910]
J Inflamm Res Clenbuterol, a Selective β2-Adrenergic Receptor Agonist, Inhibits or Limits Post-Stroke Pneumonia, but Increases Infarct Volume in MCAO Mice [Pubmed:35058704]
Cancer Commun (Lond) Anti‐PD‐L1/TGF‐βR fusion protein (SHR‐1701) overcomes disrupted lymphocyte recovery‐induced resistance to PD‐1/PD‐L1 inhibitors in lung cancer [Pubmed:34981670]
Polymers (Basel) 3D Printed Scaffold Based on Type I Collagen/PLGA_TGF-β1 Nanoparticles Mimicking the Growth Factor Footprint of Human Bone Tissue [Pubmed:35267680]
Biomed Pharmacother Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axis [Pubmed:35453007]
Biomed Pharmacother Huangbai liniment and berberine promoted wound healing in high-fat diet/Streptozotocin-induced diabetic rats [Pubmed:35430394]
Antioxidants Bio-Evaluation of the Wound Healing Activity of Artemisia judaica L. as Part of the Plant's Use in Traditional Medicine; Phytochemical, Antioxidant, Anti-Inflammatory … [Pubmed:35204215]
Frontiers in Molecular Neuroscience Red Nucleus Interleukin-6 Evokes Tactile Allodynia in Male Rats Through Modulating Spinal Pro-inflammatory and Anti-inflammatory Cytokines [Pubmed:35465093]
Vaccines Age-Dependent Dynamics of Maternally Derived Antibodies (MDAs) and Understanding MDA-Mediated Immune Tolerance in Foot-and-Mouth Disease-Vaccinated … [Pubmed:35632433]
Biomaterials Advances Human adipose-derived stem cell-loaded small intestinal submucosa as a bioactive wound dressing for the treatment of diabetic wounds in rats []
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