胰岛素(INS)重组蛋白

Recombinant Insulin (INS)

  • 胰岛素(INS)重组蛋白 产品包装(模拟)
  • 胰岛素(INS)重组蛋白 产品包装(模拟)
  • RPA448Gu01.jpg Figure. SDS-PAGE
  • Certificate 通过ISO 9001、ISO 13485质量体系认证

序列

用法

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

储存

避免反复冻融。2-8°C不超过一个月,-80°C不超过12个月。

稳定性

热稳定性以损失率显示。损失率是由加速降解试验决定,具体方法如下:在37°C孵育48小时,没有显著的降解或者沉淀产生。保质期内,在适当的条件下存储,损失率低于5%。

相关产品

编号 适用物种:Cavia (Guinea pig ,豚鼠) 应用(仅供研究使用,不用于临床诊断!)
RPA448Gu01 胰岛素(INS)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
CPA448Gu21 胰岛素(INS)卵白蛋白偶联物 Immunogen; SDS-PAGE; WB.
PAA448Gu01 胰岛素(INS)多克隆抗体 WB; IHC; ICC; IP.
PAA448Gu08 胰岛素(INS)多克隆抗体 WB; IHC; ICC; IP.
MAA448Gu21 胰岛素(INS)单克隆抗体 WB; IHC; ICC; IP.
CEA448Gu 胰岛素(INS)检测试剂盒(酶联免疫吸附试验法) Enzyme-linked immunosorbent assay for Antigen Detection.

参考文献

杂志 参考文献
Neuroscience Research Impaired neural stem/progenitor cell proliferation in Streptozotocin-induced and spontaneous diabetic mice [PubMed: 20832431]
International Journal of Nanomedicine Nicotinamide-functionalized multiwalled carbon nanotubes increase insulin production in pancreatic beta cells via MIF pathway [PubMed: PMC3770514]
Mediators of Inflammation Metformin Inhibits Expression and Secretion of PEDF in Adipocyte and Hepatocyte via Promoting AMPK Phosphorylation [Pubmed: 24288442]
American Journal of Research Communication Polo Like Kinase 1 (Plk1) Expression in Visceral Adipose Tissue of Morbidly Obese Non Diabetic Women [Usa-journals: Source]
Nutr Hosp. Effect of the “protein diet” and bone tissue. [Pubmed: 24483972]
Endocrinology Rosiglitazone Inhibits Expression and Secretion of PEDF in Adipose Tissue and Liver of Male SD Rats Via a PPAR-γ Independent Mechanism [Endocrine: Source]
CORRELA??ES ENTRE METABóLITOS E HORM?NIOS NO PERíODO DE TRANSI??O DE VACAS DE CORTE DE DIFERENTES GENóTIPOS CRIADAS NO SUL DO BRASIL [Cnptia:Source]
CONCENTRA??ES SéRICAS DE INSULINA NO PóS-PARTO RECENTE DE VACAS DE CORTE DE DIFERENTES GENóTIPOS CRIADAS NO SUL DO BRASIL [Alice:Source]
Evid Based Complement Alternat Med. Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats [Pubmed:Pmc4363645]
Iran J Basic Med Sci Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats [Pubmed:Pmc4046234]
Biometals.? Perinatal low-dose iron treatment influences susceptibility to diet-induced adipogenesis in early-aged male Wistar rats [Pubmed:24519243]
Asian Pac J Cancer Prev. Effect of NUCKS-1 Overexpression on cytokine profiling in obese women with breast cancer [Pubmed:24568505]
J Ethnopharmacol.? Antioxidative effects of Korean red ginseng in postmenopausal women: A double-blind randomized controlled trial [Pubmed:24814037]
Obes Surg Effect of Sleeve Gastrectomy Plus Side-to-Side Jejunoileal Anastomosis for Type 2 Diabetes Control in an Obese Rat Model [PubMed: 26202420]
Evid Based Complement Alternat Med Tinospora crispa [PubMed: 25821506]
international journal of biological and chemical sciences Taraxacum officinale [Index.Php: Ijbcs]
FPO IDENTIFICATION OF MODULATORS OF BINDING PROPERTIES OF ANTIBODIES REACTIVE WITH A MEMBER OF THE INSULIN RECEPTOR FAMILY [Y2015: 0301040.Html]
Nutrition Structural and functional abnormalities of hepatic tissues in male Wistar rats fed hyperwhey and super amino anabolic protein [Pubmed:27158055]
European Journal of Pharmacology Subcutaneous administration of liraglutide ameliorates learning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3尾 pathway in an amyloid 尾 protein induced alzheimer disease mouse model [Pubmed:27131827]
Archives of Physiology and Biochemistry Improvement of oral contraceptive-induced glucose dysreCavia (Guinea pig )lation and dyslipidemia by valproic acid is independent of circulating corticosterone [Pubmed:26855320]
Archives of Physiology and Biochemistry Activation of cardiac renin–angiotensin system and plasminogen activator inhibitor-1 gene expressions in oral contraceptive-induced cardiometabolic disorder [Pubmed:26934364]
Cell and Tissue Research The dynamic three-dimensional culture of islet-like clusters in decellularized liver scaffolds [Pubmed:26796204]
Adv Biomed Res. Trigonella foenum-graecum water extract improves insulin sensitivity and stimulates PPAR and γ gene expression in high fructose-fed insulin-resistant rats [pmc:PMC4817393]
Mech Ageing Dev.  Central injection of GALR1 agonist M617 attenuates diabetic rat skeletal muscle insulin resistance through the Akt/AS160/GLUT4 pathway [Pubmed:27041232]
J Bone Miner Res Fat and Sucrose Intake Induces Obesity‐Related Bone Metabolism Disturbances: Kinetic and Reversibility Studies in Growing and Adult Rats [Pubmed:26175082]
Scientific Reports Molecular characterization of insulin resistance and glycolytic metabolism in the rat uterus [pubmed:27461373]
International Journal of Medical Research Professionals Low Circulating Vaspin Level is not associated with Insulinemic Status in Impaired Glucose Tolerant Subjects [profile:Muhammad_Saiedullah]
Journal of Pharmacy and Nutrition Sciences Metformin Reduces Oxidative Stress Status and Improves Plasma Insulin Level in Streptozotocin-Induced Diabetic Rats [pms:index.php]
33 Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome. [pubmed:28336389]
Journal of Endocrinology and Metabolism Circulating Betatrophin and Hepatocyte Growth Factor in Type 2 Diabetic Patients: Their Relationship With Disease Prognosis [405]
American Journal of Translational Research Subcutaneous liraglutide ameliorates methylglyoxal-induced Alzheimer-like tau pathology and cognitive impairment by modulating tau hyperphosphorylation and glycogen synthase kinase-3β. [pubmed:28337257]
Journal of Molecular and Cellular Cardiology Irisin improves perivascular adipose tissue dysfunction via regulation of the heme oxygenase-1/adiponectin axis in diet-induced obese mice [pubmed:27638193]
Scientific Reports The anti-hyperglycemic efficacy of a lipid-lowering drug Daming capsule and the underlyingsignaling mechanisms in a rat model of diabetes mellitus. [pubmed:27721485]
Scientific Reports Adiponectin protects the rats liver against chronic intermittent hypoxia induced injury throughAMP-activated protein kinase pathway. [pubmed:27678302]
Biomedicine & Pharmacotherapy Vitamin D3 intake as regulator of insulin degrading enzyme and insulin receptor phosphorylationin diabetic rats. [pubmed:27930980]
Eur Neuropsychopharmacol. Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment. [pubmed:28063625]
Molecular and Cellular Endocrinology Baicalin against obesity and insulin resistance through activation of AKT/AS160/GLUT4 pathway [pubmed:28359800]
Diabetologia Ginsenoside Rg5 attenuates hepatic glucagon response via suppression of succinate-associated HIF-1α induction in HFD-fed mice [pubmed:28280902]
 Biochimica et Biophysica Acta (BBA)-General Subjects Modulation of gut microbiota contributes to curcumin-mediated attenuation of hepatic steatosis in rats [pubmed:28341485]
Journal of Diabetes Research High plasma glucagon levels correlate with waist-to-hip ratio, supra-iliac skinfold thickness, deep subcutaneous abdominal and intra-peritoneal adipose tissue … [2376016.pdf]
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES Berberis integerrima ameliorates insulin resistance in high-fructose-fed insulin-resistant rats [pubmed:29147484]
Journal of Functional Foods Red paprika (Capsicum annuum L.) and its main carotenoid capsanthin ameliorate impaired lipid metabolism in the liver and adipose tissue of high-fat diet-induced obese mice [10.1016:j.jff.2017.01.044]
BMJ Open Diab Res Care High circulating plasma dipeptidyl peptidase- 4 levels in non-obese Asian Indians with type 2 diabetes correlate with fasting insulin and LDL-C levels, triceps skinfolds, total intra-abdominal adipose tissue volume and presence of diabetes: a case–control study [10.1136:bmjdrc-2017-000393]
Archives of Oral Biology Chronic high-protein diet induces oxidative stress and alters the salivary gland function in rats [pubmed:28926744]
clinical and experimental pharmacology and physiology C1q/TNF‐related protein 9 improves the anti‐contractile effects of perivascular adipose tissue via the AMPK‐eNOS pathway in diet‐induced obese mice [pubmed:28902432]
Cellular Physiology and Biochemistry Irisin Regulates Heme Oxygenase-1/ Adiponectin Axis in Perivascular Adipose Tissue and Improves Endothelial Dysfunction in Diet-Induced Obese Mice [pubmed:28595178]
Peptides Activiated Galanin receptor 2 attenuates insulin resistance in skeletal muscle of obese mice [pubmed:29183756]
Journal of Diabetes Research High Plasma Glucagon Levels Correlate with Waist-to-Hip Ratio, Suprailiac Skinfold Thickness, and Deep Subcutaneous Abdominal and Intraperitoneal Adipose Tissue Depots in Nonobese Asian Indian Males with Type 2 Diabetes in North India [10.1155/2017/2376016]
Mechanisms of Ageing and Development Central injection of GALR1 agonist M617 attenuates diabetic rat skeletal muscle insulin resistance through the Akt/AS160/GLUT4 pathway [pubmed:27041232]
Iranian Journal of Pharmaceutical Research Antihyperglycemic Effect of Rosa Damascena is Mediated by PPAR.γ Gene Expression in Animal Model of Insulin Resistance [pubmed:29201096]
Obesity Surgery Effects of Bariatric Surgery on Change of Brown Adipocyte Tissue and Energy Metabolism in Obese Mice [pubmed:28853013]
Journal of Current Medical Research and Practice Relationship between serum leptin concentration and insulin resistance syndrome in patients with type 2 diabetes mellitus [issn/2357-0121]
Nanomedicine (Lond) Nanoformulated natural therapeutics for management of streptozotocin-induced diabetes: potential use of curcumin nanoformulation [pubmed:28635562]
Journal of Inorganic Biochemistry Synthesis and anti-diabetic activity of new N,N-dimethylphenylenediamine-derivatized nitrilotriacetic acid vanadyl complexes. [pubmed:28709620]
Obesity surgery The Effects of Duodenojejunal Omega Switch in Combination with High-Fat Diet and Control Diet on Incretins, Body Weight, and Glucose Tolerance in Sprague-Dawley Rats. [pubmed:28840471]
Biochemical and Biophysical Research Communications Adipose tissue complement factor B promotes adipocyte maturation. [pubmed:29137982]
Oman Medical Journal The Role of Insulin Therapy in Correcting Hepcidin Levels in Patients with Type 2 Diabetes Mellitus. [pubmed:28584599]
International Journal of Molecular Medicine Insulin restores UCP3 activity and decreases energy surfeit to alleviate lipotoxicity in skeletal muscle [pubmed:29039450]
BMC Complementary and Alternative Medicine Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin [pubmed:28576138]
Nutrients Nypa fruticans Wurmb. Vinegar's Aqueous Extract Stimulates Insulin Secretion and Exerts Hepatoprotective Effect on STZ-Induced Diabetic Rats [pubmed:28832548]
DARU Journal of Pharmaceutical Sciences Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway [pubmed:29020999]
Journal of Traditional and Complementary Medicine Improvement of spatial learning and memory, cortical gyrification patterns and brain oxidative stress markers in diabetic rats treated with Ficus deltoidea leaf extract and vitexin. [pubmed:29322009]
World Journal of Pharmaceutical Sciences The potential role of sitagliptin as an oral treatment regimen for type I diabetes mellitus [ISSN: 2321-3086]
Journal of Endocrinology Peripheral insulin resistance in ILK-depleted mice by reduction of GLUT4 expression. [pubmed:28490443]
Nature Medicine The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis [Pubmed:29291351]
Surgery for Obesity and Related Diseases The Effect of Distal-ileal Exclusion After Roux-en-Y Gastric Bypass on Glucose Tolerance and GLP-1 Response in Type-2 Diabetes Sprague-Dawley Rat Model [10.1016:j.soard.2018.07.009]
Obesity Surgery  Preserving Duodenal-Jejunal (Foregut) Transit Does Not Impair Glucose Tolerance and Diabetes Remission Following Gastric Bypass in Type 2 Diabetes Sprague … [Pubmed:29098544]
Frontiers in Physiology Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21 [Pubmed:29593555]
Chemico-Biological Interactions Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats [Pubmed:29409856]
Journal of Dairy Science Effects of dietary leucine and phenylalanine on pancreas development, enzyme activity, and relative gene expression in milk-fed Holstein dairy calves [Pubmed:29477524]
Diabetes research and clinical practice Beneficial effect of baicalin on insulin sensitivity in adipocytes of diet-induced obese mice [Pubmed:29526684]
Beneficial Microbes Anti-obesity properties of the strain subsp. CECT 8145 in Zücker fatty rats [Pubmed:29695181]
Canadian Journal of Physiology and Pharmacology Vildagliptin/pioglitazone combination improved the overall glycemic control in type I diabetic rats [Pubmed:29510081]
Animal Feed Science and Technology Effects of biotin and nicotinamide supplementation on glucose and lipid metabolism and milk production of transition dairy cows [10.1016:j.anifeedsci.2018.01.012]
Journal of Complementary and Integrative Medicine Diet enriched with fresh coconut decreases blood glucose levels and body weight in normal adults [Pubmed:29461972]
Experimental and Therapeutic Medicine Liraglutide exerts a bone‑protective effect in ovariectomized rats with streptozotocin‑induced diabetes by inhibiting osteoclastogenesis [Pubmed:29805533]
Pakistan Journal of Zoology Effects of Intrauterine Growth Retardation on Growth, Meat Quality and Muscle Fiber Composition of Pigs. [:]
Oncotarget Hyperandrogenism and insulin resistance contribute to hepatic steatosis and inflammation in female rat liver [Pubmed:29719598]
Journal of King Saud University - Science The protective effect of Azadirachta excelsa leaves extract and quercetin treatment on the learning and memory impairments in relation with insulin and amylin … [10.1016:j.jksus.2018.05.017]
Chinese Journal of Diabetes Mellitus 组织蛋白酶G 在1 型糖尿病小鼠CD+ 4T 淋巴细胞活化过程中的作用. [Ebscohost:Source]
International Journal of Molecular Sciences Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice [Pubmed: 30231545]
Journal of Functional Foods Transcriptomic analysis reveals effects of fucoxanthin on intestinal glucose transport [Doi: 10.1016/j.jff.2018.08.018]
Future Medicine Targeted folate-conjugated pluronic P85/poly(lactide--glycolide) polymersome for the oral delivery of insulin [Doi: 10.2217/nnm-2017-0372]
Cellular Physiology and Biochemistry Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice [Pubmed: 30308480]
Experimental Gerontology The decline of whole-body glucose metabolism in ovariectomized rats [Pubmed: 30292771]
Neuroscience Bulletin Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation Adrenomedullin Receptors in Rats … [Pubmed: 30276527]
Journal of Cellular Biochemistry Alterations in lipid peroxidation, lipid profile, insulin sensitivity, and hepatic histopathological changes in diabetic rats following the treatment with [Pubmed: 30270568]
Biological Rhythm Research Effects of feeding frequency during lactation in primiparous sows on reproduction performance and diurnal rhythm of endocrine profiles at the weaning-to-ovulation … []
Obesity Surgery The Changes of Serum Metabolites in Diabetic GK Rats after Ileal Transposition Surgery [Pubmed: 30397878]
Biochimie Silencing of LncRNA Steroid Receptor RNA Activator attenuates polycystic ovary syndrome in Mice [Pubmed: 30391287]
Archives of Medical Research Geniposide and Gentiopicroside Suppress Hepatic Gluconeogenesis via Regulation of AKT-FOXO1 Pathway [Pubmed: 30409503]
Biomedicine & Pharmacotherapy Effects of lycopene on metabolism of glycolipid in type 2 diabetic rats [Pubmed: 30551463]
Journal of Endocrinology Uterine progesterone signaling is a target for metformin therapy in polycystic ovary syndrome [Pubmed: 29535146]
West Indian Medical Journal Plasma Cellular Hypoxia, Mitochondrial Dysfunction, Disease Risk and Prognostic Factors in Type 2 Diabetic Patients in Saudi Arabia. []
Biomaterials Science Enhanced oral absorption of insulin using colon-specific nanoparticles co-modified with amphiphilic chitosan derivatives and cell-penetrating peptides [Pubmed: 30672923]
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of PGC-1α/GLUT4 axis-mediated glucose … [Pubmed: 30742994]
Obesity Surgery The Effect of Gastric Bypass with a Distal Gastric Pouch on Glucose Tolerance and Diabetes Remission in Type 2 Diabetes Sprague-Dawley Rat Model [Pubmed: 30778846]
Journal of Alzheimer's Disease Reports Curcumin Ameliorates the Impaired Insulin Signaling Involved in the Pathogenesis of Alzheimer's Disease in Rats []
Stress Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure [Pubmed: 30821572]
Life Sciences Interrelation of liver vascularity to non-alcoholic fatty liver through a comparative study of the vasodilator effect of carvedilol or nicorandil in rats [Pubmed: 30826497]
cell biology international Regulation of insulin resistance by targeting insulin‐like growth factor 1 receptor (IGF‐1R) with microRNA‐122‐5p in hepatic cells [Pubmed: 30958584]
international journal of molecular sciences Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice [Pubmed: 30909542]
Journal of Clinical and Translational Endocrinology Dobesity: relationship between vitamin d deficiency, obesity and sclerostin as a novel biomarker of bone metabolism []
Acta Pharmacologica Sinica Huperzine A ameliorates obesity-related cognitive performance impairments involving neuronal insulin signaling pathway in mice [Pubmed: 31213670]
Biochemistry Protective Effect of Peroxiredoxin 6 Against Toxic Effects of Glucose and Cytokines in Pancreatic RIN-m5F β-Cells []
Physiological Research Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis. [Pubmed: 31301730]
molecular nutrition & food research Glycerol Monolaurate‐Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High Fat diet‐fed Mice [Pubmed: 31318165]
Arch Physiol Biochem Associations of apelin, leptin, irisin, ghrelin, insulin, glucose levels, and lipid parameters with physical activity during eight weeks of regular exercise training [Pubmed: 31290696]
Efeito do consumo crônico de óleo de coco sobre parâmetros bioquímicos e do status redox em ratas saudáveis. []
Diabetes-Metabolism Research and Reviews Liraglutide Combined with Human Umbilical Cord Mesenchymal Stem Cell Transplantation inhibits beta‐cells apoptosis via mediating the ASK1/JNK/BAX pathway in [Pubmed: 31411368]
Phytomedicine Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK/PGC-1α pathway []
Naunyn-Schmiedebergs Archives of Pharmacology Coptisine ameliorates renal injury in diabetic rats through the activation of Nrf2 signaling pathway [Pubmed: 31420722]
Nutrients High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights … []
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