胰岛素(INS)检测试剂盒(酶联免疫吸附试验法)
ELISA Kit for Insulin (INS)
- 编号UCEA448Po
- 物种Sus scrofa; Porcine (Pig，猪) 相同的名称，不同的物种。
- 实验方法竞争抑制
- 反应时长2h
- 检测范围61.7-5,000pg/mL
- 灵敏度最小可检测剂量小于等于23.5pg/mL.
- 样本类型serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
- 下载 英文说明书 中文说明书
- 规格 48T96T 96T*5 96T*10 96T*100
- 价格 ¥ 1025 ¥ 1464 ¥ 6588 ¥ 12444 ¥ 102480
- 欲了解实际交易价格和更多情况，请与当地经销商联系!
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产品包装(模拟)
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产品包装(模拟)
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实验结果图
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标准曲线图
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通过ISO 9001、ISO 13485质量体系认证
特异性
本试剂盒用于检测胰岛素(INS)，经检测与其它相似物质无明显交叉反应。
由于受到技术及样本来源的限制，不可能完成对所有相关或相似物质交叉反应检测，因此本试剂盒有可能与未经检测的其它物质有交叉反应。
回收率
分别于定值血清及血浆样本中加入一定量的胰岛素(INS)（加标样品），重复测定并计算其均值，回收率为测定值与理论值的比率。
| 样本 | 回收率范围(%) | 平均回收率(%) |
| serum(n=5) | 78-103 | 89 |
| EDTA plasma(n=5) | 94-105 | 99 |
| heparin plasma(n=5) | 88-97 | 92 |
精密度
精密度用样品测定值的变异系数CV表示。CV(%) = SD/mean×100
批内差：取同批次试剂盒对低、中、高值定值样本进行定量检测,每份样本连续测定20 次，分别计算不同浓度样本的平均值及SD值。
批间差：选取3个不同批次的试剂盒分别对低、中、高值定值样本进行定量测定，每个样本使用同一试剂盒重复测定8次，分别计算不同浓度样本的平均值及SD值。
批内差： CV<10%
批间差： CV<12%
线性
在定值血清及血浆样本内加入适量的胰岛素(INS)，并倍比稀释成1:2，1:4，1:8，1:16的待测样本，线性范围即为稀释后样本中胰岛素(INS)含量的测定值与理论值的比率。
| 样本 | 1:2 | 1:4 | 1:8 | 1:16 |
| serum(n=5) | 89-103% | 98-105% | 80-93% | 88-102% |
| EDTA plasma(n=5) | 83-97% | 79-99% | 83-95% | 80-99% |
| heparin plasma(n=5) | 86-102% | 82-94% | 99-105% | 78-101% |
稳定性
经测定，试剂盒在有效期内按推荐温度保存，其活性降低率小于5%。
为减小外部因素对试剂盒破坏前后检测值的影响，实验室的环境条件需尽量保持一致，尤其是实验室内温度、湿度及温育条件。其次由同一实验员来进行操作可减少人为误差。
实验流程
1. 实验前标准品、试剂及样本的准备；
2. 加样（标准品及样本）50µL，
加入50µL检测液A(临用前配制);
37°C温育1小时。
3. 洗板3次；
4. 加检测溶液B100µL，37°C孵育30分钟；
5. 洗板5次；
6. 加TMB底物90µL，37°C孵育10-20分钟；
7. 加终止液50µL，立即450nm读数。
实验原理
本试剂盒应用竞争抑制酶联免疫分析法测定标本中待测物质水平。将胰岛素(INS)单克隆抗体包被微孔板，制成固相载体，往包被抗体的微孔中同时加入生物素标记的抗原和待测抗原(标准品或样本)，待测抗原与生物素标记抗原对特异性抗体进行竞争结合。温育后经洗涤去掉未结合物，然后加入HRP标记的亲和素，经过温育和彻底洗涤后加入底物TMB显色。TMB在过氧化物酶的催化下转化成蓝色，并在酸的作用下转化成最终的黄色。待测标本浓度越高，标记抗原和抗体的结合就越受到抑制，显色愈浅。显色的深浅与酶量呈正相关，而与样品中待测物质含量呈负相关。用酶标仪在450nm波长下测定吸光度（O.D.值），计算样品浓度。
增值服务
相关产品
| 编号 | 适用物种：Sus scrofa; Porcine (Pig，猪) | 应用(仅供研究使用，不用于临床诊断！) |
| URPA448Po02 | 胰岛素(INS)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| URPA448Po01 | 胰岛素(INS)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UCPA448Po21 | 胰岛素(INS)卵白蛋白偶联物 | Immunogen; SDS-PAGE; WB. |
| UPAA448Po02 | 胰岛素(INS)多克隆抗体 | IHC |
| UPAA448Po01 | 胰岛素(INS)多克隆抗体 | WB; IHC; ICC; IP. |
| UCEA448Po | 胰岛素(INS)检测试剂盒(酶联免疫吸附试验法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| ULMA448Po | 胰岛素(INS)等多因子检测试剂盒(流式荧光发光法) | FLIA Kit for Antigen Detection. |
| UKSA448Po11 | 胰岛素(INS)检测试剂盒DIY材料(酶联免疫吸附试验法) | Main materials for "Do It (ELISA Kit) Yourself". |
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| Journal of Hazardous Materials | Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice [Pubmed: 31796355] |
| Journal of Steroid Biochemistry and Molecular Biology | SerpinB1 promotes the proliferation of porcine pancreatic stem cells through the STAT3 signaling pathway [Pubmed: 31785377] |
| Journal of dermatological treatment | Liraglutide improved inflammation via mediating IL-23/Th-17 pathway in obese diabetic mice with psoriasiform skin [Pubmed: 31868553] |
| Nutrients | Rotundic Acid Protects against Metabolic Disturbance and Improves Gut Microbiota in Type 2 Diabetes Rats [Pubmed: 31887996] |
| JOURNAL OF DAIRY SCIENCE | Decreased amylolytic microbes of the hindgut and increased blood glucose implied improved starch utilization in the small intestine by using rumen-protected leucine … [Pubmed: 32113753] |
| Biomed Pharmacother | Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice [Pubmed: 32035395] |
| Frontiers in Endocrinology | Hyperbaric oxygen ameliorates insulin sensitivity by increasing GLUT4 expression in skeletal muscle and stimulating UCP1 in brown adipose tissue in T2DM … [Pubmed: 32082261] |
| Cell Physiol Biochem | Integrin Linked Kinase (ILK) Downregulation as an Early Event During the Development of Metabolic Alterations in a Short-Term High Fat Diet Mice Model. [Pubmed: 31972071] |
| JOURNAL OF FOOD SCIENCE | Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats [Pubmed: 32249934] |
| Journal of Diabetes Research | Roux-en-Y Gastric Bypass in Obese Diabetic Rats Promotes Autophagy to Improve Lipid Metabolism through mTOR/p70S6K Signaling Pathway [Pubmed: 32309446] |
| Brain Research | Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway [Pubmed: 32304687] |
| endocrine journal | Mice with nucleus tractus solitarius injury induced by chronic restraint stress present impaired ability to raise blood glucose and glucagon levels when blood glucose … [Pubmed: 32249244] |
| Frontiers in Endocrinology | RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis [Pubmed: 32328034] |
| Antioxidants | Effects of Allicin on Pathophysiological Mechanisms during the Progression of Nephropathy Associated to Diabetes [Pubmed: 33203103] |
| Nature Communications | AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis [Pubmed: 33199780] |
| EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | Evaluation of the hypoglycemic effect of exendin-4's new oral self-nanoemulsifying system in rats [Pubmed: 33197556] |
| BIOLOGICAL RESEARCH | Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance … [Pubmed: 33109277] |
| FASEB JOURNAL | Irradiation of carotid baroreceptor with low‐intensity pulsed ultrasound exerts different metabolic protection in perirenal, epididymal white adipose tissue and … [Pubmed: 32954574] |
| Biol Res | Palmatine ameliorates high fat diet induced impaired glucose tolerance [Pubmed: 32928312] |
| ENDOCRINE | Thioredoxin-interacting protein: a critical link between autophagy disorders and pancreatic β-cell dysfunction [Pubmed: 32892310] |
| DIABETOLOGIA | Adiponectin treatment improves insulin resistance in mice by regulating the expression of the mitochondrial-derived peptide MOTS-c and its response to exercise via … [Pubmed: 32880686] |
| AMERICAN JOURNAL OF PATHOLOGY | Insulin promotes corneal nerve repair and wound healing in type 1 diabetic mice by enhancing Wnt/β-catenin signaling [Pubmed: 32858016] |
| MEDIATORS OF INFLAMMATION | Aplysin Retards Pancreatic Necrosis and Inflammatory Responses in NOD Mice by Stabilizing Intestinal Barriers and Regulating Gut Microbial Composition [Pubmed: 32801992] |
| EUROPEAN JOURNAL OF PHARMACOLOGY | Gut microbiota modulation as a promising therapy with metformin in rats with non-alcoholic steatohepatitis: Role of LPS/TLR4 and autophagy pathways [Pubmed: 32758573] |
| ARCHIVES OF GYNECOLOGY AND OBSTETRICS | MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistance [Pubmed: 32757043] |
| CHEMICO-BIOLOGICAL INTERACTIONS | Modulatory role of imatinib mesylate on pancreatic β-cells' secretory functions in an STZ rat model of diabetes mellitus [Pubmed: 32710900] |
| Mol Med | Electroacupuncture alleviates polycystic ovary syndrome-like symptoms through improving insulin resistance, mitochondrial dysfunction, and endoplasmic … [Pubmed: 32698821] |
| JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | Highly Branched RG-I Domain Enrichment are Indispensable for Pectin Mitigating Against High-Fat Diet-Induced Obesity [Pubmed: 32633953] |
| Scientific Reports | Integrated metabolomics and gut microbiome to the effects and mechanisms of naoxintong capsule on type 2 diabetes in rats [Pubmed: 32616735] |
| J Endocrinol Invest | Activation of central galanin receptor 2 mitigated insulin resistance in adipocytes of diabetic rats [Pubmed: 32588381] |
| J Chem Neuroanat | The neuroprotective effect of simvastatin on the cerebellum of experimentally-induced diabetic rats through klotho upregulation: An immunohistochemical study [Pubmed: 32479899] |
| Journal of Diabetes Research | Regulation and Mechanism of miR-518d through the PPARα-Mediated NF-κB Pathway in the Development of Gestational Diabetes Mellitus [Pubmed: 33123597] |
| Journal of Cellular and Molecular Medicine | Cooperative effects of galanin and leptin on alleviation of insulin resistance in adipose tissue of diabetic rats [Pubmed: 32395890] |
| BioMed Research International | Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress [Pubmed: 32685488] |
| Frontiers in Pharmacology | MiR-185-5p Protects Against Angiogenesis in Polycystic Ovary Syndrome by Targeting VEGFA [Pubmed: 32760272] |
| Iranian Journal of Basic Medical Sciences | Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression as a novel component in a rat model of PCOS [] |
| Nutrition & Metabolism | Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut … [] |
| Journal of Functional Foods | Different source of commercial vegetable oils may regulate metabolic, inflammatory and redox status in healthy rats [] |
| Comparative transcriptomic and metabolomic analysis reveals pectoralis highland adaptation across altitudinal songbirds [] | |
| The effects of different intensity endurance and resistance exercise on diabetic-related blood profiles in impaired glucose tolerance mice [] | |
| Cell Death & Disease | Phosphorylation of eIF2¦Á signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner [33318479] |
| Ther Adv Chronic Dis | Empagliflozin improves chronic hypercortisolism-induced abnormal myocardial structure and cardiac function in mice [33294147] |
| Physiol Behav | Time-restricted feeding attenuates gluconeogenic activity through inhibition of PGC-1¦Á expression and activity [33412190] |
| PLoS Genetics | Physiological and genetic convergence supports hypoxia resistance in high-altitude songbirds [33370292] |
| Mol Med Rep | N1?methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC?1¦Á signaling pathway [33576435] |
| Arch Endocrinol Metab | Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional study [33740335] |
| Sci Rep | Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl: ZUC (ORL)-Lepr fa) rats [33833309] |
| PeerJ | miR-155-5p upregulation ameliorates myocardial insulin resistance via mTOR signaling in chronic alcohol drinking rats [33868799] |
| JOURNAL OF FOOD BIOCHEMISTRY | Identification of curcumin as a potential ¦Á©\glucosidase and dipeptidyl©\peptidase 4 inhibitor: Molecular docking study, in vitro and in vivo biological evaluation [33817806] |
| JOURNAL OF NUTRITIONAL BIOCHEMISTRY | Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver?¡ [33915261] |
| Cell Metab | TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease [34107313] |
| Dapagliflozin: a Sodium-glucose Cotransporter 2 Inhibitor, Attenuates Angiotensin II-induced Cardiac Fibrotic Remodeling by Regulating TGF¦Â1/Smad ¡ [34116674] | |
| EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY | Different Ratios of Corn and Coconut Oil Blends in High©\Fat Diets Influence Fat Deposition without Altering Metabolic Biomarkers in Male Rats [] |
| Journal of Alzheimer's disease | DAla2-GIP-GLU-PAL Protects Against Cognitive Deficits and Pathology in APP/PS1 Mice by Inhibiting Neuroinflammation and Up-regulating cAMP/PKA/CREB?¡ [] |
| International Journal of Diabetes in Developing Countries | Investigation of extracellular matrix genes associated with Alzheimer's disease in the hippocampus of experimental diabetic model rats [] |
| researchsquare | Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats [] |
| Cells Tissues Organs | Intermittent Fasting Attenuates High Fat Diet-Induced Cerebellar Changes in Rats: Involvement of TNFα, autophagy and oxidative stress [34551416] |
| Experimental Biology and Medicine | Bee venom ameliorates cardiac dysfunction in diabetic hyperlipidemic rats [34550826] |
| Phytomedicine | Baicalin protects against insulin resistance and metabolic dysfunction through activation of GALR2/GLUT4 signaling [34923235] |
| Pharmacol Res | Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability [34896249] |
| Eat Weight Disord | Time-restricted feeding prevents metabolic diseases through the regulation of galanin/GALR1 expression in the hypothalamus of mice [34370270] |
| Food Chem Toxicol | Combined treatment of sinapic acid and ellagic acid attenuates hyperglycemia in streptozotocin-induced diabetic rats [34329744] |
| Eur J Pharmacol | Spexin ameliorates skeletal muscle insulin resistance through activation of GAL2 receptor [Pubmed:34973950] |
| Surgical Endoscopy | The effect of bariatric surgery on the expression of Growth Differentiation Factor-15/Macrophage-Inhibitory Cytokine-1 (GDF-15/MIC-1) in rat [Pubmed:35029766] |
| Arch Biochem Biophys | ATP6V1H deficiency impairs glucose tolerance by augmenting endoplasmic reticulum stress in high fat diet fed mice [Pubmed:34990584] |
| Environ Sci Pollut Res Int | Environmental exposure to low-dose perfluorohexanesulfonate promotes obesity and non-alcoholic fatty liver disease in mice fed a high-fat diet [Pubmed:35217953] |
| Naunyn Schmiedebergs Arch Pharmacol | Intragastric safflower yellow and its main component HSYA improve leptin sensitivity before body weight change in diet-induced obese mice [Pubmed:35201390] |
| PLoS One | A cross-sectional comparative study on the effects of body mass index and exercise/sedentary on serum asprosin in male college students [Pubmed:35381008] |
| Cell Death & Disease | Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance [Pubmed:35347118] |
| Endocr J | A novel anti-obesity mechanism for liraglutide by improving adipose tissue leptin resistance in high-fat diet-fed obese mice [Pubmed:35705299] |
| Antioxidants | Antioxidant Effect of Tyr-Ala Extracted from Zein on INS-1 Cells and Type 2 Diabetes High-Fat-Diet-Induced Mice [Pubmed:35740008] |
| Mol Cell Endocrinol | Treatment with spexin mitigates diet-induced hepatic steatosis in vivo and in vitro through activation of galanin receptor 2 [Pubmed:35654225] |
| Biofabrication | Dual-core coaxial bioprinting of double-channel constructs with a potential for perfusion and interaction of cells [Pubmed:35616388] |
| Ecotoxicology and Environmental Safety | Constitutional delay of growth and puberty in female mice is induced by circadian rhythm disruption in utero [Pubmed:35679725] |
| SAUDI J BIOL SCI | Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus rats by reducing blood glucose levels and enhancing brain … [Pubmed:35531250] |
| Saudi Pharmaceutical Journal | Sukkari dates seed improves type-2 diabetes mellitus-induced memory impairment by reducing blood glucose levels and enhancing brain cholinergic … [Pubmed:35812141] |
| Turk J Diab Obes | An Investigation of the Effect of Curcumin on Fructose-Induced Metabolic Syndrome Rat Models [] |
| Journal of Drug Delivery Science and Technology | Miglitol-PMO nanoparticles, an alpha-glucosidase inhibitor, has prolonged action on blood glucose level in diabetic rats [] |
| Genes & Diseases | Prolonged control of insulin-dependent diabetes via intramuscular expression of plasmid-encoded single-strand insulin analogue [] |
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