M2-型丙酮酸激酶(PKM2)重组蛋白
Recombinant Pyruvate kinase isozymes M2 (PKM2)
M2PK; PKM; M2-PK; PKM1; CTHBP; OIP3; PK3; PKM; TCB; THBP1; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; Cytosolic thyroid hormone-binding protein; Pyruvate Kinase, Muscle
- 编号RPA588Hu01
- 物种Homo sapiens (Human，人) 相同的名称，不同的物种。
- 来源原核表达
- 宿主E.coli
- 内毒素水平<1.0EU/µg(LAL法测定)
- 亚细胞定位细胞核, 细胞质
- 预测分子量13.4kDa
- 实际分子量13kDa(差异分析请参阅说明书)
- 片段与标签Lys141~Ala248 with N-terminal His Tag
- 缓冲液成份20mM Tris, 150mM NaCl缓冲液（pH8.0, 含有1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose和Proclin300）
- 性状冻干粉
- 纯度> 97%
- 等电点5.4
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应用
Positive Control; Immunogen; SDS-PAGE; WB.
如果需要有生物活性的蛋白，请参见活性蛋白。 - 下载 英文说明书 中文说明书
- 规格 10µg50µg 200µg 1mg 5mg
- 价格 ¥ 1104 ¥ 2760 ¥ 5520 ¥ 16560 ¥ 41400
- 欲了解实际交易价格和更多情况，请与当地经销商联系!
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产品包装(模拟)
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产品包装(模拟)
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Figure . Gene Sequencing (extract)
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Figure. SDS-PAGE
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通过ISO 9001、ISO 13485质量体系认证
序列
用法
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
储存
避免反复冻融。2-8°C不超过一个月，-80°C不超过12个月。
稳定性
热稳定性以损失率显示。损失率是由加速降解试验决定，具体方法如下：在37°C孵育48小时，没有显著的降解或者沉淀产生。保质期内，在适当的条件下存储，损失率低于5%。
增值服务
相关产品
| 编号 | 适用物种：Homo sapiens (Human，人) | 应用(仅供研究使用，不用于临床诊断！) |
| RPA588Hu01 | M2-型丙酮酸激酶(PKM2)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA588Hu02 | M2-型丙酮酸激酶(PKM2)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA588Hu03 | M2-型丙酮酸激酶(PKM2)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA588Hu02 | M2-型丙酮酸激酶(PKM2)活性蛋白 | Cell culture; Activity Assays. |
| PAA588Hu02 | M2-型丙酮酸激酶(PKM2)多克隆抗体 | WB; IHC; IF;FCM |
| PAA588Hu03 | M2-型丙酮酸激酶(PKM2)多克隆抗体 | WB; IHC; ICC; IP. |
| PAA588Hu01 | M2-型丙酮酸激酶(PKM2)多克隆抗体 | WB,IHC,ICC/IF |
| FAA588Hu01 | 抗M2-型丙酮酸激酶(PKM2)多克隆抗体 | Flow cytometry. |
| FAA588Hu03 | 抗M2-型丙酮酸激酶(PKM2)多克隆抗体 | Flow cytometry. |
| MAA588Hu22 | M2-型丙酮酸激酶(PKM2)单克隆抗体 | WB; IHC; ICC; IP. |
| MAA588Hu23 | M2-型丙酮酸激酶(PKM2)单克隆抗体 | WB; IHC; ICC; IP. |
| MAA588Hu21 | M2-型丙酮酸激酶(PKM2)单克隆抗体 | WB; IHC; ICC; IP. |
| SEA588Hu | M2-型丙酮酸激酶(PKM2)检测试剂盒(酶联免疫吸附试验法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMA588Hu | M2-型丙酮酸激酶(PKM2)等多因子检测试剂盒(流式荧光发光法) | FLIA Kit for Antigen Detection. |
参考文献
| 杂志 | 参考文献 |
| Cancer Research | Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3 [AACR: 70189] |
| Molecular BioSystems | Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer [Pubmed:25483567] |
| Tumour Biol | M2 isoform of pyruvate kinase (PKM2) is upregulated in Kazakh’s ESCC and promotes proliferation and migration of ESCC cells [PubMed: 26404132] |
| Oncotarget | Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholangitis [Pubmed:29707118] |
| Journal of Neurotrauma | Acteoside improves muscle atrophy and motor function by inducing new myokine secretion in chronic spinal cord injury [Pubmed: 30318996] |
| Cell Reports | Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway [Pubmed: 32049010] |
| Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC) [] | |
| Cancer Cell International | Bufalin Induced Mitochondrial Dysfunction Promotes Apoptosis of Glioma Cells by Regulating Annexin A2 and DRP1 Proteins [] |
| Cancer Cell Int | Bufalin induces mitochondrial dysfunction and promotes apoptosis of glioma cells by regulating Annexin A2 and DRP1 protein expression [34376212] |
| Life (Basel) | Putative Association between Low Baseline Gene Expression in the Peripheral Blood and Clinical Remission in Rheumatoid Arthritis Patients Treated with Tofacitinib [34947916] |
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